Farshad Nadri; Ali Khavanin; Zohreh Mazaheri; Farahnaz Khajehnasiri
Volume 20, Issue 12 , 2018, Pages 1-7
Abstract
Background: Noise is one of the harmful environmental factors and an inevitable phenomenon in workplaces. Noise stress can lead to endocrine and reproductive system disorders. Objectives: This experimental study was conducted to investigate the effect of noise stress on sperm parameters and the protective ...
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Background: Noise is one of the harmful environmental factors and an inevitable phenomenon in workplaces. Noise stress can lead to endocrine and reproductive system disorders. Objectives: This experimental study was conducted to investigate the effect of noise stress on sperm parameters and the protective effect of hydroalcoholic Cinnamomum verum extract in adult rats. Methods: A total of 32 male Wistar rats were randomly assigned to four groups (n = 8). Group 1 was treated with distilled water (con- trol), Group 2 was treated with 75 mg kg-1 hydroalcoholic C. verum extract, Group 3 was exposed to noise (100 dB) for the eighth/day, and Group 4 was exposed to noise and treated with 75 mg kg-1 hydroalcoholic C. verum extract by gavage. After 50 days, the rats were anesthetized, blood samples were collected, and the cauda epididymis was removed to examine sperm parameters. Data analysis was performed using SPSS.Results: In Group 3, noise stress significantly decreased the levels of sex hormones (LH, FSH, and testosterone), sperm viability, and the percentage of morphologically normal sperm compared to the control group. In Group 2, the levels of sex hormones and sperm parameters increased significantly compared to the control group. Comparison of the results of Groups 3 and 4 showed the protective effect of C. verum extract on the levels of sex hormones and sperm viability.Conclusions: It is recommended to investigate the action mechanism of C. verum effect on the male reproductive system of animal models and humans who work in noisy environments.
Raheleh Hashemi Habybabady; Seyed Bagher Mortazavi; Ali Khavanin; Ramazan Mirzaei
Volume 19, Issue 3 , March 2017, , Pages 1-9
Abstract
Background: Previous studies demonstrated partial attenuation of noise induced hearing loss (NIHL) by N-acetyl-L-cysteine (NAC) or CoQ10 (ubiquinone).Objectives: The present study investigates the protection effect of coadministration of NAC and CoQ10 against NIHL.Methods: In an experimental study in ...
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Background: Previous studies demonstrated partial attenuation of noise induced hearing loss (NIHL) by N-acetyl-L-cysteine (NAC) or CoQ10 (ubiquinone).Objectives: The present study investigates the protection effect of coadministration of NAC and CoQ10 against NIHL.Methods: In an experimental study in Iran in 2015, a total of 36 male Wistar rats (275 ± 25 g) were divided randomly based on the permuted block design into 6 experimental groups: (I) noise controls, (II) noise and NAC, (III) noise and CoQ10, (IV) noise and CoQ10 and NAC, (V) noise and saline (as vehicle of NAC) and (VI) noise and olive oil (as vehicle of CoQ10). Antioxidants and vehicles were intraperitoneally injected once a day for two days prior to and 1 hour before 102±0.5 dB white noise exposure 8 h/day in 10 executive days and two days after the noise exposure daily. Distortion product otoacoustic emissions were measured one day before and 1, 7 and 21 days after the exposure.Results: The temporary hearing changes that occurred 1-day post exposure were not significantly different in all groups (P > 0.05). The total recovery (between 1 - 21 days after noise exposure) varied by a frequency increase between 1.08 - 19.10 in the noise group compared to 1.75 - 24.5 and 0.62 - 22.08 in animals treated with NAC and the combination of NAC and CoQ10 respectively. The less permanent hearing impairment was observed in noise exposed animals treated with either NAC or both NAC and CoQ10.Conclusions: The effect of coadministration of NAC and CoQ10 was neither additive nor synergic in protecting against NIHL.
